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High Blood Cholesterol: What You Need To Know
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High Blood Cholesterol: What You Need To Know
Why Is Cholesterol Important?Your blood cholesterol level has a lot to do with your chances of getting heart disease. High blood cholesterol is one of the major risk factors for heart disease. A risk factor is a condition that increases your chance of getting a disease. In fact, the higher your blood cholesterol level, the greater your risk for developing heart disease or having a heart attack. Heart disease is the number one killer of women and men in the United States. Each year, more than a million Americans have heart attacks, and about a half million people die from heart disease.
How Does Cholesterol Cause Heart Disease?When there is too much cholesterol (a fat-like substance) in your blood, it builds up in the walls of your arteries. Over time, this buildup causes "hardening of the arteries" so that arteries become narrowed and blood flow to the heart is slowed down or blocked. The blood carries oxygen to the heart, and if enough blood and oxygen cannot reach your heart, you may suffer chest pain. If the blood supply to a portion of the heart is completely cut off by a blockage, the result is a heart attack.
High blood cholesterol itself does not cause symptoms, so many people are unaware that their cholesterol level is too high. It is important to find out what your cholesterol numbers are because lowering cholesterol levels that are too high lessens the risk for developing heart disease and reduces the chance of a heart attack or dying of heart disease, even if you already have it. Cholesterol lowering is important for everyone--younger, middle age, and older adults; women and men; and people with or without heart disease.
What Do Your Cholesterol Numbers Mean?Everyone age 20 and older should have their cholesterol measured at least once every 5 years. It is best to have a blood test called a "lipoprotein profile" to find out your cholesterol numbers. This blood test is done after a 9- to 12-hour fast and gives information about your:
- Total cholesterol
- LDL (bad) cholesterol--the main source of cholesterol buildup and blockage in the arteries
- HDL (good) cholesterol--helps keep cholesterol from building up in the arteries
- Triglycerides--another form of fat in your blood
If it is not possible to get a lipoprotein profile done, knowing your total cholesterol and HDL cholesterol can give you a general idea about your cholesterol levels. If your total cholesterol is 200 mg/dL* or more or if your HDL is less than 40 mg/dL, you will need to have a lipoprotein profile done. See how your cholesterol numbers compare to the tables below.
Total Cholesterol Level
Less than 200 mg/dL
240 mg/dL and above
* Cholesterol levels are measured in milligrams (mg) of cholesterol per deciliter (dL) of blood.
LDL Cholesterol Level
Less than 100 mg/dL
Near optimal/above optimal
190 mg/dL and above
HDL (good) cholesterol protects against heart disease, so for HDL, higher numbers are better. A level less than 40 mg/dL is low and is considered a major risk factor because it increases your risk for developing heart disease. HDL levels of 60 mg/dL or more help to lower your risk for heart disease.
Triglycerides can also raise heart disease risk. Levels that are borderline high (150-199 mg/dL) or high (200 mg/dL or more) may need treatment in some people.
A variety of things can affect cholesterol levels. These are things you can do something about:
Diet. Saturated fat and cholesterol in the food you eat make your blood cholesterol level go up. Saturated fat is the main culprit, but cholesterol in foods also matters. Reducing the amount of saturated fat and cholesterol in your diet helps lower your blood cholesterol level.
Weight. Being overweight is a risk factor for heart disease. It also tends to increase your cholesterol. Losing weight can help lower your LDL and total cholesterol levels, as well as raise your HDL and lower your triglyceride levels.
Physical Activity. Not being physically active is a risk factor for heart disease. Regular physical activity can help lower LDL (bad) cholesterol and raise HDL (good) cholesterol levels. It also helps you lose weight. You should try to be physically active for 30 minutes on most, if not all, days.
Things you cannot do anything about also can affect cholesterol levels. These include:
Age and Gender. As women and men get older, their cholesterol levels rise. Before the age of menopause, women have lower total cholesterol levels than men of the same age. After the age of menopause, women's LDL levels tend to rise.
Heredity. Your genes partly determine how much cholesterol your body makes. High blood cholesterol can run in families.
In general, the higher your LDL level and the more risk factors you have (other than LDL), the greater your chances of developing heart disease or having a heart attack. Some people are at high risk for a heart attack because they already have heart disease. Other people are at high risk for developing heart disease because they have diabetes (which is a strong risk factor) or a combination of risk factors for heart disease. Follow these steps to find out your risk for developing heart disease.
Step 1: Check the table below to see how many of the listed risk factors you have; these are the risk factors that affect your LDL goal.
Major Risk Factors That Affect Your LDL Goal
High blood pressure (140/90 mmHg or higher or on blood pressure medication)
Low HDL cholesterol (less than 40 mg/dL)*
Family history of early heart disease (heart disease in father or brother before age 55; heart disease in mother or sister before age 65)
Age (men 45 years or older; women 55 years or older)
* If your HDL cholesterol is 60 mg/dL or higher, subtract 1 from your total count.
Even though obesity and physical inactivity are not counted in this list, they are conditions that need to be corrected.
Step 2: How many major risk factors do you have? If you have 2 or more risk factors in the table above, use the attached risk scoring tables (which include your cholesterol levels) to find your risk score. Risk score refers to the chance of having a heart attack in the next 10 years, given as a percentage. My risk score is ________%.
Step 3: Use your medical history, number of risk factors, and risk score to find your risk of developing heart disease or having a heart attack in the table below.
If You Have
You Are in Category
Heart disease, diabetes, or risk score more than 20%*
I. High Risk
2 or more risk factors and risk score 10-20%
II. Next Highest Risk
2 or more risk factors and risk score less than 10%
III. Moderate Risk
0 or 1 risk factor
IV. Low-to-Moderate Risk
* Means that more than 20 of 100 people in this category will have a heart attack within 10 years.
My risk category is ______________________.
The main goal of cholesterol-lowering treatment is to lower your LDL level enough to reduce your risk of developing heart disease or having a heart attack. The higher your risk, the lower your LDL goal will be. To find your LDL goal, see the boxes below for your risk category. There are two main ways to lower your cholesterol:
Therapeutic Lifestyle Changes (TLC)--includes a cholesterol-lowering diet (called the TLC diet), physical activity, and weight management. TLC is for anyone whose LDL is above goal.
Drug Treatment--if cholesterol-lowering drugs are needed, they are used together with TLC treatment to help lower your LDL.
If you are in...
Category I, Highest Risk, your LDL goal is less than 100 mg/dL. you will need to begin the TLC diet to reduce your high risk even if your LDL is below 100 mg/dL. If your LDL is 100 or above, you will need to start drug treatment at the same time as the TLC diet. If your LDL is below 100 mg/dL, you may also need to start drug treatment together with the TLC diet if your doctor finds our risk is very high, for example if you had a recent heart attack or have both heart disease and diabetes.
Category II, Next Highest Risk, your LDL goal is less than 130 mg/dL. If your LDL is 130 mg/dL or above, you will need to begin treatment with the TLC diet. If your LDL is 130 mg/dL or more after 3 months on the TLC diet, you may need drug treatment along with the TLC diet. If your LDL is less than 130 mg/dL, you will need to follow the heart healthy diet for all Americans, which allows a little more saturated fat and cholesterol than the TLC diet.
Category III, Moderate Risk, your LDL goal is less than 130 mg/dL. If your LDL is 130 mg/dL or above, you will need to begin the TLC diet. If your LDL is 160 mg/dL or more after you have tried the TLC diet for 3 months, you may need drug treatment along with the TLC diet. If your LDL is less than 130 mg/dL, you will need to follow the heart healthy diet for all Americans.
Category IV, Low-to-Moderate Risk, your LDL goal is less than 160 mg/dL. If your LDL is 160 mg/dL or above, you will need to begin the TLC diet. If your LDL is still 160 mg/dL or more after 3 months on the TLC diet, you may need drug treatment along with the TLC diet to lower your LDL, especially if your LDL is 190 mg/dL or more. If your LDL is less than 160 mg/dL, you will need to follow the heart healthy diet for all Americans.
To reduce your risk for heart disease or keep it low, it is very important to control any other risk factors you may have such as high blood pressure and smoking.
TLC is a set of things you can do to help lower your LDL cholesterol. The main parts of TLC are:
The TLC Diet. This is a low-saturated-fat, low-cholesterol eating plan that calls for less than 7percent of calories from saturated fat and less than 200 mg of dietary cholesterol per day. The TLC diet recommends only enough calories to maintain a desirable weight and avoid weight gain. If your LDL is not lowered enough by reducing your saturated fat and cholesterol intakes, the amount of soluble fiber in your diet can be increased. Certain food products that contain plant stanols or plant sterols (for example, cholesterol-lowering margarines) can also be added to the TLC diet to boost its LDL-lowering power.
Weight Management. Losing weight if you are overweight can help lower LDL and is especially important for those with a cluster of risk factors that includes high triglyceride and/or low HDL levels and being overweight with a large waist measurement (more than 40 inches for men and more than 35 inches for women).
Physical Activity. Regular physical activity (30 minutes on most, if not all, days) is recommended for everyone. It can help raise HDL and lower LDL and is especially important for those with high triglyceride and/or low HDL levels who are overweight with a large waist measurement.
Foods low in saturated fat include fat-free or 1percent dairy products, lean meats, fish, skinless poultry, whole grain foods, and fruits and vegetables. Look for soft margarines (liquid or tub varieties) that are low in saturated fat and contain little or no trans fat (another type of dietary fat that can raise your cholesterol level). Limit foods high in cholesterol such as liver and other organ meats, egg yolks, and full-fat dairy products.
Good sources of soluble fiber include oats, certain fruits (such as oranges and pears) and vegetables (such as brussels sprouts and carrots), and dried peas and beans.
Alternatives to Statin Drugs
By Ben Lynch
Huge topic. I can write a book on this but best not yet! Two more years of med school yet and by then I'll be even more versed in how to lower cholesterol naturally.
First: What is cholesterol?
According to Stedman's Medical Dictionary, cholesterol is "the most abundant steroid in animal tissues, especially in bile and gall stones, and present in food, especially rich in animal fats, circulates in plasma complexed to proteins of various densities and plays an important role in the pathogenesis of atheroma formation in arteries."
What is pathogenesis of atheroma? It is the beginning stage of atherosclerosis which is the building of lipid [cholesterol] plaques within the structure of arteries. These plaques narrow the vessel wall thereby limiting the flow of blood. Limiting the flow of blood causes turbulence which causes further deposition of plaque. The slowed speed of blood through the arteries helps lay down more plaque as well.
Ways to lower cholesterol naturally:
Exercise: damn. How many times do you have to hear it - everyone says it. Because it works better than any drug out there. Why does it work? Simple biochemistry and physiology. Exercise requires energy. Energy comes from sugars, fats and proteins. When the sugars and proteins are burned, fats must be converted into useable forms of energy. The liver steps up by making good cholesterol, HDL. HDL goes around and picks up bad cholesterol, LDL. It converts this into useable energy. So, by exercising, your energy requirements increase thereby lowering cholesterol naturally. Exercise 30 minutes a day as often as you can in a week. Try one day a week and build up. You'll become addicted to it. Better that than statins.
Eat soluble fiber: Where can you find that? In beans and whole grains. The FDA's page on fiber is not too shabby. Fruits and vegetables contain insoluble fiber. Soluble fiber actually binds to cholesterol removing it from your body. Insoluble fiber adds bulk to your stools making you more regular - which is extremely vital as well.
Limit animal fat foods: damn again. Even Stedman's Medical Dictionary said cholesterol is the most abundant steroid in animal tissues. They didn't say plant tissues. I'm not saying avoid it completely. Just keep an eye on it - don't chomp down endless roast beef sandwhiches with mayo and four kinds of cheese.
Inositol: This is time-released niacin in the no-flush form. Niacin is a main player in cellular metabolism. If one is low in niacin, then the energy reactions do not go forward. If they do not go forward, lipids accumulate which is directly tied to high levels of choleterol. A study on time-released niacin shows its effectiveness. The study I found used pharmaceutical time-released niacin but I believe these two are very similar - with the natural form being superior. The bottom line of the study: "The results show that niacin ER [extended release] produces a beneficial effect on lipoprotein subclasses, specifically decreasing the more atherogenic small, dense LDL particles and enhancing the cardioprotective large HDL particles." Remember what I said about bad LDL and good HDL? The inositol sounds pretty good now doesn't it?
Red Yeast Rice: This is what the pharmaceutical companies make some statin drugs from - directly! So why not take it in its natural state? It works quite well. It works by limiting the cholesterol reaction from going forward. This means that cholesterol's production is slowed down thereby lowering cholesterol naturally. I have found a great research article on PubMed for Red Yeast Rice. The research was done by the Center for Human Nutrition and is not biased by a natural supplement company. Here is the study: Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement.
Policosanol: This is sugar wax. Sound safe? It is. It does not turn off the cholesterol forming reaction as strongly as statin drugs. Our bodies need some cholesterol formed. Without it, numerous hormones would not be made and we would be dead. Thus, it is better to moderately limit production rather than severly limit. Policosanol has also shown to increase the levels of HDL. Do statin drugs do this? No. There is a good study on this that I found on PubMed. You'll notice it is not a study made by a natural supplement company or with biased interests. Here it is: Comparison of the efficacy and tolerability of policosanol with atorvastatin in elderly patients with type II hypercholesterolaemia
This natural cholesterol lowering supplement is made by Biogenesis. Bio Lipotrol has Red Yeast Rice, Inositol, Policosanol and Guggal Gum extract. I work for Biogenesis and have preceptored with Dr David Wood. I have visited with physician after physician that have used Bio Lipotrol and the results are seen within a couple weeks. Now this doesn't mean you can sit on your couch eating hamburgers and pizza while popping Bio Lipotrol capsules. I have already stated that exercise is the best medicine - along with the limitation of animal fats and an increase in soluble fiber. I did not know about Bio Lipotrol until a classmate kept buying it. I found her in the hall one day and asked her what it is. She told me it is working very well on her grandmother's high cholesterol levels. Then I became more interested. The benefits of being in med school - you find what works and what doesn't.
What are the dangers of Statin drugs?
I don't know all of the dangers but I know one that is not often addressed. Statin drugs give the false impression that the one taking them does not have to be proactive in lowering cholesterol. If a drug is lowering cholesterol without them doing anything, why not chomp on fatty foods? I'll tell you why. Statin drugs limit the production of cholesterol. They do not limit the intake of cholesterol. You do.
Also - statin drugs seriously limit the production of Coenzyme Q10. This is a major energy source for the human heart and electron transport chain. So if you are on statin drugs, take CoQ10. I believe statin drugs also limit the conversion of active Vitamin D. This I need to check on but it makes sense if following the reactions down from HMG-CoA, which is the limiting step in cholesterol synthesis.
If you want to lower cholesterol naturally, these steps will no doubt help you. I recommend having a sit-down chat with your physician. Most docs will listen to you and be supportive and knowledgable about this arena. If not, find a licensed and qualified naturopathic physician who will listen to you.
This information is not telling you to stop taking your statin drugs. It is merely information. Do not stop your statin drugs without consulting with your physician. Only then, under their direction, stop the meds if you implement other means.
If you are not on statin drugs and you don't have money to see a doctor, these steps may help you lower cholestrol naturally. But as I am not a doctor yet, I am not prescribing any of this information to you. It is up to you.
I hope you are still awake. That is a ton of information. I know I'm wiped. I've got to get away from this computer now.
"( Red Yeast Rice )" Lowers High Cholesterol Naturally - 150 Capsules 1200 mg In Two Capsules!"Red Yeast Rice Complex" contains ingredients to help your body lower cholesterol naturally, the main ingredient being Red Yeast Rice. Read the study below from UCLA School of Medicine on Red Yeast Rice lowering cholesterol!
(Ingredients in 2 capsules)
Red Yeast Rice 1200 mg,
Suggested use 2 Capsules Daily. 120 Capsules per bottle
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If you've been waiting for solid scientific evidence before trying Red Yeast Rice Extract to lower your cholesterol, there's been a rigorous trial from the UCLA School of Medicine. The UCLA study was published in the American Journal of Clinical Nutrition in 1999 and confirmed that a supplement known as Red Yeast Rice Extract reduces cholesterol levels by an average of 40 points in 12 weeks when combined with a low-fat diet. That's about the same result you'd expect from a low dose of the popular cholesterol drug, Mevacor.
Red Yeast Rice Extract contains a number of cholesterol-lowering compounds known as statins, among them lovastatin, the same active ingredient that's in Mevacor. Other red yeast compounds are similar to those in other cholesterol medications, such as Lipitor (atorvastatin) and Zocor (simvastatin).
For people with high cholesterol (240 mg/dl or above), the choice among conventional physicians is usually to prescribe one of the statin drugs. "It's particularly important to talk to your doctor about drugs if you have very high cholesterol or heart disease," advises Michael Cirigliano, M.D., associate professor of medicine at the University of Pennsylvania School of Medicine. Not only do these drugs quickly and effectively lower cholesterol levels, but studies show that they directly lead to a reduced risk of heart attack. They also tend to be safe, although there is a slight risk of serious side effects, such as liver problems or severe muscle aches.
For those with borderline cholesterol (200 to 239 mg/dl), the decision is trickier. A five-year study showed that statin drugs cut the risk of heart disease in this group, too. But some experts believe that natural supplements may offer similar benefits, with fewer adverse effects. However, long-term studies are lacking. Several trials in China have shown that red yeast products have no toxic effects, and in the UCLA study, the liver tests of people taking the supplement remained normal. A five-year study of the safety of red yeast extract is underway.
Cost may be a deciding factor as well. A month's supply of lovastatin runs about $100, compared with $17.99 for Red Yeast Extract.
More Information on Red Yeast Rice.
As a substance, red yeast rice extract has a number of heart-healthy benefits: It seems to help reduce total cholesterol levels, lower levels of LDL ("bad") cholesterol, increase levels of HDL ("good") cholesterol, and lower levels of unhealthy fats called triglycerides. It appears to accomplish this by restricting the liver's production of cholesterol. The compound responsible for this effect
is chemically identical to the cholesterol-lowering compound lovastatin. Unsaturated fatty acids in red yeast rice extract are also believed to be beneficial, possibly by lowering triglycerides.
By lowering cholesterol concentrations, red yeast rice extract may help to prevent heart disease and some of its complications. Individuals with moderately elevated cholesterol levels (200 to 239 mg/dL) may benefit from a dietary supplement such as red yeast rice extract. However, those with very high cholesterol levels (240 mg/dL or above) are at considerable risk for heart disease and should stick to prescription drugs with a proven ability to rapidly and effectively reduce cholesterol levels.
The best way to achieve and maintain a healthy cholesterol level is to take heart-healthy substances such as red yeast rice extract as part of an overall regimen that includes exercise and a low-fat diet that is high in soluble fiber. Most studies of the extract that showed a substantial cholesterol-lowering effect (reduction of 25 to 40 points) included such lifestyle measures.
If you choose to incorporate red yeast rice into your cholesterol-lowering program, it is very important to remember that you are taking a substance that acts identically in the body to the prescription statin drugs. This means that red yeast rice can cause the same side effects (mild gastrointestinal upset and possible changes in liver enzymes, or a muscle condition called rhabdomyolysis). Research studies have shown red yeast rice to be remarkably safe, but of course, you should not use it if you are also taking a prescription statin.
General Interaction ********* There are no known drug or nutrient interactions associated with red yeast rice. However, there are interactions associated with lovastatin. Prescription statin drugs such as lovastatin can reduce levels of coenzyme Q10, an antioxidant produced by the heart and other tissues to protect cells from damage. Some experts recommend supplementing a regimen of red yeast extract (or other statin drugs) with this nutrient.
Don't mix red yeast rice extract with other statin-type cholesterol-lowering medications, or you may risk consuming excessive amounts of particular ingredients. However, red yeast rice can be safely combined with niacin supplements for additional cholesterol-lowering effects.
Cautions Consult your doctor before taking red yeast rice or any other cholesterol-lowering dietary supplement. This is particularly important if you have high cholesterol or heart disease.
Take red yeast rice extract with food to reduce the risk of digestive upset.
Side effects with red yeast rice extract have been reported but tend to be mild and resolve quickly once you stop taking it. These include headache, dizziness, heartburn, gas, and digestive tract discomfort. Stop taking red yeast rice extract and consult a doctor promptly if you experience any side effects that seem more severe or persistent than these.
Keep in mind that, in theory, the statins in red yeast rice extract pose the risk of rare but serious reactions, including skeletal muscle damage, liver damage, and kidney toxicity. Approximately 1% to 2% of people taking the drug lovastatin have such reactions. Symptoms may include unexplained weakness, muscle pains and tenderness, and other flu-like symptoms. It's still unclear whether these types of reactions occur with people taking standardized red yeast rice extract, however. In a recent, 12-week clinical trial, for example, liver and kidney function in the participants remained normal.
Red Yeast Rice Extract - 150 Vegetarian Capsules
150 Vegetarian Capsules Description:
Red Yeast Rice (Monascus purpureus) has been used for centuries in the Chinese diet as a staple food and for its health benefits.* 21st Century.s Red Yeast Rice Extract has been quality tested to assure maximum benefit. Instructions:
Keep out of reach of children. Do not use if product appears to be tampered with or seal is broken. Store at room temperature. Warning:
Do not take if you are pregnant or breast-feeding. Consult your medical practitioner before using this product. This product is for adult use only. For Your Health:
Unconditionally guaranteed for purity, freshness and label potency. No Sugar, Salt, Preservatives or Artificial Flavors. Directions:
Take up to two (2) vegetarian capsules daily with any meal, or as directed by a health care provider. Not to exceed 4 capsules in a 24 hour period.
To avoid possible complications due to the statin content in red yeast rice extract, don't take this supplement if you are pregnant or breast-feeding, or if you have liver disease, a serious infection, or a transplanted organ. Also avoid it if you have recently had major surgery.
Don't take red yeast rice extract if you are younger than age 20.
Avoid drinking more than two alcoholic drinks a day or large amounts of grapefruit juice while taking red yeast rice extract.
The information provided on this site should not be construed as personal medical advice or instruction. No action should be taken based solely on the contents of this site. Readers should consult appropriate health professionals on any matter relating to their health and well-being. The information and opinions provided here are believed to be accurate and sound, based on the best judgment available to the authors, but readers who fail to consult appropriate health authorities assume the risk of any injuries. The publisher is not responsible for errors or omissions.
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"( Choless Control)" Lowers Cholesterol Naturally With Policosanol Most Powerful Cholesterol Lowering Supplement On The Market!
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Choless Control cholesterol control formula with Policosanol to reduce cholesterol naturally.
Choless Control with policosanol is the most effective formula available for a safe and natural means to help lower cholesterol in the body.
Policosanol, the primary ingredient in .Choless-Control., has been clinically proven to lower total cholesterol levels by as much as 25.9% in just 8 weeks!
Choless Control Product Ingredients:
Two 2-Piece Capsules Provide
Policosanol 10 MG
Policosanol has been shown to normalize cholesterol as well or better than cholesterol-lowering drugs, without side effects such as liver dysfunction and muscle atrophy.1 Efficacy and safety have been proven in numerous clinical trials, and it has been used by millions of people in other countries. Policosanol lowers harmful LDL-cholesterol and raises protective HDL-cholesterol. HDL-cholesterol removes plaque from arterial walls.
Policosanol is a natural supplement derived from sugar cane. The main ingredient is octacosanol. Octacosanol is an alcohol found in the waxy film that plants have over their leaves and fruit. The leaves and rinds of citrus fruits contain octacosanol, and so does wheat germ oil.
Policosanol helps stop the formation of artery lesions,2 an effect similar to that of statin drugs. This was proven in studies on rabbits fed a diet designed to create high cholesterol. According to researchers "in most policosanol-treated animals, atherosclerotic lesions were not present, and in others, thickness of fatty streaks had less foam cell layers than in controls.,3
Policosanol also inhibits the oxidation of dangerous LDL-cholesterol4 which promotes the destruction of blood vessels by creating a chronic inflammatory response. Oxidized LDL can also provoke metalloproteinase enzymes.5 These enzymes promote blood vessel destruction, partly by interfering with HDL's protective effect. Studies show that rats treated with policosanol have fewer foam cells, reflecting less inflammatory response causing less blood vessel destruction.6,7
Healthy arteries are lined with a smooth layer of cells so that blood can race through with no resistance. One of the features of diseased arteries is that this layer becomes thick and overgrown with cells. As the artery narrows, blood flow slows down or is blocked completely. Policosanol can stop the proliferation of these cells in much the same was as lipid-lowering drugs.8,9
Policosanol also inhibits the formation of clots, and may work synergistically with aspirin in this respect. In a comparison of aspirin and policosanol, aspirin was better at reducing one type of platelet aggregation (clumping together of blood cells). But policosanol was better at inhibiting another type. Together, policosanol and aspirin worked better than either alone.10,11
Thromboxane is a blood vessel-constricting agent that contributes to abnormal platelet aggregation that can cause a heart attack or stroke. Significant reductions in the level of thromboxane occur in humans after two weeks of policosanol.12
People with elevated LDL-cholesterol (over 100) or low HDL-cholesterol (under 50) should seek to protect themselves from the potentially fatal effects of cardiovascular disease. Some people can achieve optimal cholesterol levels via dietary modification, while others require intervention with dietary supplements like policosanol or prescription drugs.
Some people will not achieve adequate results with policosanol or FDA-approved cholesterol-lowering drugs. That is why it is so important to have your blood tested when using policosanol (or FDA-approved drugs). Some people will only require 5 mg to 10 mg a day of policosanol, while others may need 20 mg/day. The same dosage variation may be true of cholesterol-lowering drugs.
A standard blood chemistry profile measures total cholesterol, LDL-cholesterol, HDL-cholesterol and numerous other parameters such as liver and kidney function. By taking this blood test two months after beginning policosanol, you can adjust the dose to meet your individual need.
Niacin 50 MG Niacin (vitamin B3) improves cholesterol profiles when given in doses well above the vitamin requirement. Nicotinic acid lowers total cholesterol, LDL-cholesterol, and triglyceride levels, while raising HDL-cholesterol levels. Most people cannot use the doses (1000 to 3000 mg a day) of niacin required to suppress cholesterol levels. Niacin causes a flushing effect, resembling an acute allergic reaction that many people find intolerable. While niacin is considered relatively safe, like other cholesterol-lowering drugs, it can cause liver toxicity when taken in high doses. Monitoring liver enzymes every 6 months is important when taking more than 1000 mg of niacin a day. Those with hepatitis should avoid niacin.
Flush-free niacin may lower cholesterol while boosting the beneficial HDL fraction. In a report on the antiatherogenic role of HDL (high density lipoprotein) cholesterol, flush-free niacin (inositol hexanicotinate) "appears to have the greatest potential to increase HDL cholesterol [by] 30%." This study was made over a 5-year period and focused on the effect of high LDL numbers exhibited before a patient's first coronary event(s).
As reported in a November 1998 American Journal of Cardiology research study, "Nicotinic acid (niacin) has been shown to decrease triglyceride, increase HDL cholesterol, lower LDL cholesterol, and decrease lipoprotein (a); it also decreases fibrinogen," an additional benefit that reduces the risk of related cardiovascular disease. To determine whether lower doses of nicotinic acid are as effective and better-tolerated than the typical regimen currently used, researchers at the University of Texas Southwestern Medical Center in Dallas, as reported and described in the Archives of Internal Medicine, 1996, conducted a trial using two different doses (1.5 g and 3.0 g) of nicotinic acid.
The results showed that the lower dose (1.5 g ) nicotinic acid treatment significantly lowered triglyceride levels, raised HDL concentrations by approximately 22%, and favorably altered the ratio of total cholesterol: HDL cholesterol in both normal patients and those with abnormal lipid levels at baseline. Further improvement in lipid levels was also observed in those patients who tolerated the higher dose of nicotinic acid. In this study, significant improvement in blood lipids levels was observed among the 75% of patients who tolerated low-dose nicotinic acid therapy. The authors conclude that use of nicotinic acid in lower doses than traditionally prescribed is both well-tolerated and effective in altering blood lipid levels. In addition, they suggest that this vitamin may be particularly worthwhile when combined with other lipid-lowering medications.
Gugulipid (2.5% gugglesterones) 100 MG
This powerful ancient remedy has been re-discovered by Western culture. Gugulipid is made from the resin of the commiphora mukul tree of north central India. Gugulipid (gugulesterones) has been used for thousands of years to alleviate problems associated with obesity, acne, viral infections, and other ailments. In a study published in 1989 by the Journal of Associated Physicians-India, 125 patients receiving gugulipid showed an 11% decrease in total serum cholesterol, a drop of 16.8% in triglycerides, and a 60% increase in HDL cholesterol within 3 to 4 weeks. Patients with elevated cholesterol levels showed much greater improvement than normal patients.
The study quoted a second trial (included in the article noted above) where 205 patients receiving gugulipid at a dose rate of 25 mg administered 3 times daily showed a 70 to 80% reduction of serum cholesterol, whereas no response was found in the placebo group (Journal of Associated Physicians-India, 1989, 37:328).
A placebo-controlled trial of 40 patients with high blood-fat levels showed a serum cholesterol reduction of 21.75%, with triglycerides being reduced by 27.1% in only 3 weeks, and after continuing the study for 16 weeks it was learned that HDL cholesterol was increased by 35.8% (Journal of Associated Physicians-India, 1989, 37:328).
Plant Sterol Complex 200 MG
Phytosterols (PS) or plant sterols are structurally similar to cholesterol which causes the absorption of cholesterol to be blocked through competitive inhibition.. Studies suggest that dietary plant sterols may offer protection from the most common cancers in Western societies, such as colon, breast and prostate cancer
Garlic (herb powder) 50 MG
A study published in the Journal Nutrition Research (1987, 7:139-49) showed that a liquid garlic extract made by Kyolic caused a 12 to 31% reduction in cholesterol levels in the majority of test subjects after 6 months. The study showed that 73% of the subjects given the Kyolic garlic experienced a greater than 10% reduction in cholesterol, compared with only 17% of the subjects in the placebo group showing the same improvement. If you have high LDL cholesterol levels, garlic supplementation is especially important because LDL cholesterol oxidation causes atherosclerosis, and garlic specifically inhibits LDL oxidation. And garlic helps protect the arterial lining against oxidation. Most importantly, garlic prevents abnormal platelet aggregation (thrombosis) via several different mechanisms. The formation of arterial blood clots is the primary cause of most heart attacks and strokes.
Investigators reported in a study published in the American Journal of Clinical Nutrition (1996, 64:866-70) that the daily administration of 7.2 grams of Kyolic garlic powder for 6 months produced a modest reduction (of between 6.1 and 7%) in total cholesterol, compared with the placebo group. The more dangerous LDL cholesterol was reduced 4 to 4.6% in the Kyolic group.
The heart-healthy benefits of garlic include protecting the endothelial lining of the arterial system against oxidative damage. A study published in Atherosclerosis (1999, 144:237-49) shows an actual reduction in buildup of fatty plaque in arteries in garlic-supplement users. Fatty plaque is comprised of many substances, including cholesterol. When plaque accumulates in the coronary arteries, the condition can lead to heart attack. In a study of 280 adults, German researchers reported that participants who took 900 mg of garlic powder a day had up to 18% less plaque in their arteries than those who took a placebo, or "dummy," powder. Male study participants who took a placebo had a 5.5% increase in plaque volume, while those who took the garlic powder experienced just a 1.1% increase in plaque buildup during the 4-year study period. By comparison, women who took the garlic showed a 4.6% decrease in plaque volume, while those who took the placebo powder had a 5.3% increase. Garlic may affect plaque buildup by reducing blood platelet stickiness (aggregation) and specifically preventing the oxidation of LDL cholesterol onto the lining of the arteries. Platelet aggregation helps plaque cling to the arteries.
An April 1998 study reported on the effect of garlic on blood lipids, blood sugar fibrogen, and fibrinogenic activity of 30 patients who received 4 grams of garlic daily for 3 months. The patients were monitored at 1.5 and 3 months when it was determined that garlic had "significantly reduced total serum cholesterol and triglycerides, and significantly increased HDL cholesterol." With regard to fibrinogenic activity, it was determined that the garlic inhibited platelet aggregation (Prostagland. Leuk. Essent. Fatty Acids, April 1998, 58:257-63).
An earlier study in June 1994, the University of Massachusetts Medical School published a report that found that those U.S. adults who consumed one-half to one clove of garlic each day showed cholesterol levels that were reduced by 9% (JAMA, June 1, 1994, 271:1660-61). A survey of 7 out of 8 studies on garlic showed that dosages of between 600 to 900 mg of garlic powder (Allium sativum L.) produced a 5 to 20% reduction in cholesterol and triglycerides. (Fortschr. Med. (Germany) 1990, 108:49-54). Other studies have shown that much higher doses of garlic were required for cholesterol reduction.
Human patients fed a daily dose of Kyolic ("Aged Garlic Extract") over a 10-month study showed that "adhesion to fibrinogen was reduced by 30%-compared to placebo . . . and that . . . the beneficial effect of garlic preparations on lipids and blood pressure extends also to platelet function" (Journal of Cardiovascular Pharmacology [United States], 1998, 31:904-8).
Note: Overall studies seem to indicate that dosages of garlic may be a factor in its efficacy. The suggested dose of high allicin garlic extract should be between 6000 mg and 8000 mg daily taken with meals. Since large amounts of garlic may cause stomach upset, we recommend that garlic be taken with the largest meal of the day.
In summary, the mechanisms by which garlic have shown to protect against cardiovascular disease include the following: cholesterol reduction, preventing abnormal blood clot formation inside of blood vessels; protecting against LDL cholesterol oxidation; and protecting the endothelial lining of the arterial system against oxidation. A review of all the studies on garlic indicates that high doses are required for effective cholesterol reduction. If you were to use garlic alone to lower serum cholesterol, you should take 6000 to 8000 mg a day. When used in combination with other cholesterol-lowering nutrients, lower doses of garlic may be effective.
Cayenne Pepper ...................50 MG
Inhibits LDL oxidation
other ingredients: gelatin, rice four, vegetable stearate and stearic acid
Policosanol should only be taken by people who have high serum cholesterol levels. The optimal range of total serum cholesterol is between 180 and 200 mg/dL. Cholesterol levels below 180 cause an increased risk of mortality and levels below 150 may be very dangerous. It may be particularly risky for people over age 70 to have cholesterol levels below 150-180. DO NOT TAKE policosanol if it causes serum cholesterol to drop below 150-180 mg/dL. Anyone supplementing with policosanol should check their total, LDL- and HDL-cholesterol levels within 8 weeks of beginning treatment to make sure they are taking the proper amount to modify cholesterol to the optimal safe ranges. If you are currently taking cholesterol-lowering drugs, you should notify your doctor if you plan to use policosanol instead of, or in addition to these drugs. Some people who do not adequately suppress cholesterol with drug therapy may choose to add policosanol to achieve better cholesterol control. Pregnant or nursing Women should not take this product without consulting with a healthcare professional. When using nutritional supplements, please inform your healthcare professional if you are undergoing treatment for a medical condition. Note: These statements have not been evaluated by the Food and Drug Administration. Policosanol is a dietary supplement and not a drug approved by the FDA
Niacin (Niacinamide) - 50 mg
Policosanol - 10 mg
Gugulipid (2.5% gugglesterones) - 100 mg
Plant Sterol Complex
Cayenne (herb powder)
Garlic (herb powder) - 50 mg
Niacin (Niacinamide) - 50 mg
Other Ingredients - Gelatin, Rice Flour, Vegetable Stearate and Stearic Acid.
Serving Size - 2 Capsules
Availability: Usually ships the next business day.
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