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********Why People Use CoQ10 by 21 Century! 45 Capsules********
Heart failure
Cardiomyopathy
Heart Attack Prevention and Recovery
High Blood Pressure
Diabetes
Gum Disease
Kidney Failure
Migraine
Counteract Prescription Drug Effects
Parkinson's disease
Weight loss
*******WHAT IS COQ10 PRIMARILY USED FOR?*************
Although CoQ10 is beneficial in many health aspects, its primary nutritional use is to support energy metabolism. The heart has very high energy demands and very high concentrations of CoQ10. Extensive Japanese research has shown CoQ10 to be an effective dietary supplement with diverse cardiovascular benefits. In 1977, Karl Folkers, Watanabe and Kaji made a critique of the published research regarding CoQ10 from the previous ten years. The numerous Japanese publications were translated into English summaries which included data from 110 physicians and 41 medical institutions in Japan.
As a result of the overwhelmingly positive reports, including 2 clinical double-blind trials, the Japanese Government granted approval in 1974 for CoQ10 to be marketed. The widespread use of CoQ10 by physicians in Japan steadily increased to such a high level that by 1982, CoQ10 became one of the most widely used products by the entire Japanese Pharmaceutical industry.
CoQ10 may also be effective in maintaining healthy blood pressure. Studies by Yamagami (1975, 1986) AND Digiesi (1990) indicated that CoQ10 may be a "significant" adjunct as a dietary supplement.
********WHAT ELSE IS COQ10 USED FOR?********
CoQ10 may be considered an anti-aging supplement because its levels decline up to 80% in the body as we age. Because CoQ10 declines in the body over time, it is linked to fundamental aging processes and may be a causative factor in aging itself. E.Bliznaker showed that female mice increased their lifespan 56% while under CoQ10 supplementation.
CoQ10 is involved in energy production in all types of people. Without CoQ10, you would not have enough energy to stay alive! Because of the importance of CoQ10 in aerobic energy production, it is quite popular among serious athletes and sports enthusiats.
CoQ10 is a potent antioxidant as demonstrated in 1996 by Mellars and Toppel. Clinical studies by Karlson (1986) Zierz (1989) and others have demonstrated that CoQ10 is a therapeutically efective agent in diseases due to free radical damage. CoQ10 is a free radical scavenger that inhibits lipid peroxidation - a normal compnent of aging in humans that can contribute to many diseases. Numerous studies suggest CoQ10 to be an effective antioxidant that helps to maintain healthy intra-cellular activity. CoQ10 has been compared to vitamin E for its role as an antioxidant in several studies since 1965.
CoQ10 may be helpful in maintaining healthy gum tissue. A 1967 study by Tsunemitso and Matsumura pioneered work on periodontal patients using CoQ10 under diverse conditions with the general conclusion that CoQ10 is of benefit to their patients.
*********What is CoQ10?************
Coenzyme Q-10 has been established as one of the most intensively studied cardio protective nutrients. It is vital for the generation of all cellular energy for muscles, enzyme actions and respiration. Coenzyme Q10 supplementation can contribute to your health and overall energy and stamina. It is a powerful antioxidant and acts as a cell - membrane stabilizer against free radicals.
Coenzyme Q-10 is a quinone that functions as an electron transfer agent between cytochromes in the Krebs or energy cycle. In its version known as coenzyme Q-10 (CoQ10) or ubiquinol, this nutrient has become well known as a product that will increase your cellular energy.
CoQ10 is an enzyme found in all cells of the body. It occurs naturally, and is the co-factor in the electron transport chain between cells. CoQ10 is located in the mitochondria, tiny power plants found in every cell in the body, and effectively supports their energy producing pathways to help fuel the body's daily activity. If you lack CoQ10, your body's most important source of cellular energy is depleted, and many medical conditions are aggravated. It is most concentrated in the heart and liver, and is a vital component in the mitochondria, the body's metabolic factories. The best source for CoQ10 is in a high-quality liquid multivitamin.
CoQ10 is a powerful antioxidant, scavenging free radicals, sitting in the membranes with Vitamin E which it recycles to keep it most active. Studies have shown that it helps combat various forms of cardiovascular disease, and reduces the number and size of certain tumors and is useful in treating gum disease. Yet, it was not well known or understood for until lately.
CoQ10’s discovery dates back to 1957. CoQ10 is not a vitamin. Vitamins are nutrients that cannot be manufactured by the body, but must be ingested. CoQ10 is manufactured by the body, but rarely in sufficient amounts to confer significant health benefits. Therefore, CoQ10 is "vitamin-like" and needs to be taken as a nutritional supplement.
CoQ10 is widely recommended to repair heart damage and to boost the function of the heart, as well as in preventative use to safeguard against heart attacks and valve damage. It has also been shown to be beneficial in breast and lung cancer, as well as helping to maintain cognitive function.
CoQ10 reduces many of the serious side effects of cholesterol and other prescription drugs such as beta blockers. It also reduces the effects of aging. It helps in the recovery from a wide range of heart problems including angina pectoris, congestive heart failure and mitral valve prolapse and with reducing blood pressure and blood lipids. CoQ10 assists chronic fatigue sufferers when administered at higher doses and helps you build and strengthen your immune system. CoQ10 also helps in stabilizing your blood pressure and it helps your brain function optimally.
CoQ10 taken at 100mg a day increases aerobic activity and protects your heart muscle. While coenzyme Q does occur naturally in all fruits and vegetables, it is difficult to get enough of it on a daily basis from food alone. Men who have proven coronary heart disease should consider taking 300mg of coenzyme Q a day, as should women with breast cancer. This dosage has been shown to increase survival times in women with that disease. CoQ10 has been found to be effective for treating congestive heart failure in double-blind, placebo-controlled trial. Its efficacy for angina is not yet as firmly proven, although studies are quite promising.
Medications used to lower cholesterol lower plasma concentrations of CoQ10. Oral anti-diabetic medications can also potentially inhibit the effects of CoQ10.
CoQ10 has also been found to be useful in treating Parkinson’s disease, the second most common neurodegenerative disorder after Alzheimer's disease affecting approximately 1% of the population older than 50 years. Note that you should not consult your doctor before takeing CoQ01o if you have liver or kidney disease or if you suffer from diabetes. CoQ10) is a naturally occurring anti-oxidant.
Taken orally, coenzyme Q-10 may help treat congestive heart failure and delay the progression of Parkinson's disease. It may also be useful in treating diseases including muscular dystrophy, AIDS, hypertension, and mitochondrial diseases. There is recent evidence that it may also increase sperm motility. Unfortunately, sometimes touted for enhancing athletic performance, this hasn't been well demonstrated yet. In summary, CoQ10 has a wide assortment of incredible benefits. The only downside is the cost - CoQ10 can sometimes be a tad expensive. CoQ10 supplements are preferable in liquid form because liquids absorb 5 times better than pills.
Other Names: Coenzyme Q10, Co Q10, Ubiquinone, Vitamin Q
CoQ10 is a naturally-occuring compound found in every cell in the body. CoQ10's alternate name, ubiquinone, comes from the word ubiquitous, which means "found everywhere."
CoQ10 plays a key role in producing energy in the mitochondria, the part of a cell responsible for the production of energy in the form of ATP.
*******What is the Evidence For CoQ10?********
Heart failure
People with heart failure have been found to have lower levels of CoQ10 in heart muscle cells. Double-blind research suggests that CoQ10 may reduce symptoms related to heart failure, such as shortness of breath, difficulty sleeping, and swelling. CoQ10 is thought to increase energy production in the heart muscle, increasing the strength of the pumping action. Recent human studies, however, haven't supported this.
In one study, 641 people with congestive heart failure were randomized to receive either CoQ10 (2 mg per kg body weight) or a placebo plus standard treatment. People who took the CoQ10 had a significant reduction in symptom severity and fewer hospitalizations.
In another study, 32 patients with end-stage heart failure awaiting heart transplantation received either 60 mg of CoQ10 or a placebo for 3 months. Patients who took the CoQ10 experienced a significant improvement in functional status, clinical symptoms, and quality of life, however there were no changes in echocardiogram (heart ultrasound) or in objective markers.
A study randomized 55 patients with congestive heart failure to receive either 200 mg per day of CoQ10 or a placebo in addition to standard treatment. Although serum levels of CoQ10 increased in patients receiving CoQ10, CoQ10 didn't affect ejection fraction, peak oxygen consumption, or exercise duration.
A longer-term study investigated the use of 100 mg of CoQ10 or a placebo in addition to standard treatment in 79 patients with stable chronic congestive heart failure. The results indicated that CoQ10 only slightly improved maximal exercise capacity and quality of life compared with the placebo.
Cardiomyopathy
Several small trials have found CoQ10 may be helpful for certain types of cardiomyopathy.
Parkinson's disease
Lower levels of CoQ10 have also been observed in people with Parkinson's disease. Preliminary research has found that increasing CoQ10 may increase levels of the neurotransmitter dopamine, which is thought to be lowered in people with Parkinson's disease. It has also been suggested that CoQ10 might protect brain cells from damage by free radicals.
A small, randomized controlled trial examined the use of 360 mg CoQ10 or a placebo in 28 treated and stable Parkinson's disease patients. After 4 weeks, CoQ10 provided a mild but significant significant mild improvement in early Parkinson's symptoms and significantly improved performance in visual function.
A larger 16 month trial funded by the National Institutes of Health explored the use of CoQ10 (300, 600 or 1200 mg/day) or a placebo in 80 patients with early stage Parkinson's disease. The results suggested that CoQ10, especially at the 1200 mg per day dose, had a significant reduction in disability compared to those who took a placebo.
CoQ10 and Statin Drugs
Some research suggests that statin drugs, or HMG-CoA reductase inhibitors, a class of drugs used to lower cholesterol, may interfere with the body's production of CoQ10. However, research on the use of CoQ10 supplements in people taking statins is still inconclusive, and it is not routinely recommended in combination with statin therapy.
Diabetes
In a 12-week randomized controlled trial, 74 people with type 2 diabetes were randomized to receive either 100 mg CoQ10 twice daily, 200 mg per day of fenofibrate (a lipid regulating drug), both or neither for 12 weeks. CoQ10 supplementation significantly improved blood pressure and glycemic control. However, two studies found that CoQ10 supplementation failed to find any effect on glycemic control.
Gum disease
A small study looked at the topical application of CoQ10 to the periodontal pocket. Ten male periodontitis patients with 30 periodontal pockets were selected. During the first 3 weeks, the patients applied topical CoQ10. There was significant improvement in symptoms.
********Which form of CoQ10 is best?*********
In two separate studies, we compared the relative bioavailability of CoQ10 in commercially available products, i.e., an oil suspension in softgel, powder-filled hard-shelled capsules, a tablet formula, and Q-Gel, a new solubilized CoQ10 formula in a softgel (using the new biosolv process).
These two studies, each involving 24 healthy volunteers, demonstrated that the bioavailability of CoQ10 can be greatly enhanced by using appropriate solubilization techniques.
With Q-Gel, plasma CoQ10 values showed a sharp increase, reaching a therapeutic range above 2.5 ug/ml within three to four weeks with further increases over time.
Although the optimal dose of CoQ10 is not known for every pathological situation, researchers agree that levels of 2.5 ug/ml and preferably 3.5 ug/ml'8,'9 are required to have a positive impact on severely diseased hearts. Therefore, whenever employing CoQ10 as a supplement, it is important to note not only the amount being taken, but also how it is absorbed and delivered to the body.
Product bioavailability is obviously a major concern to consumers. All CoQ10 is made in Japan and sold to various companies, but the packaging and preparations differ. New research shows that the delivery of CoQ10 in softsules, which are both water- and fat-soluble, is superior to the dry form; more CoQ10 gets into the bloodstream.
********How much CoQ10 should I take?********
Keeping delivery in mind, what dose of CoQ10 should one take? Whether taking capsules, cap-tabs or regular oilbased CoQ10, my recommendations are as follows:
30 to 100 mg daily as a preventive in cardiovascular or periodontal disease and for patients taking Hmg-CoA reductase inhibitors.
90 to 180 mg daily for the treatment of angina pectoris, cardiac arrhythmia, high blood pressure and moderate gingival disease.
180 to 360 mg daily for congestive heart failure and dilated cardiomyopathy.
Note: For a severely impaired immune system, as in cancer, even higher doses of CoQ10 may be required.
Once a therapeutic effect is obtained, that is, there is improved well-being, lowered blood pressure, improved shortness of breath, better gum tissues, and so on, the maintenance dose may be adjusted. Fifteen mg of Q-Gel softsule is the equivalent of approximately 50 mg of standard CoQ10.
It has been observed that for many cardiac conditions, especially CHF and cardiomyopathy, the therapeutic dose must be the maintenance dose or symptoms will return. I have noted that some patients, well-maintained on CoQ10, will have a return of symptoms if they change the brand or the dosage they are taking. Obviously, they may be getting a poorer delivery system, but if the situation is not remedied, their cardiac symptoms may return and the cause may not be recognized. Stopping or reducing CoQ10 is similar to altering intake of cardiac drugs such as beta blockers. Relapses can certainly occur.
For those using CoQ10 as adjunct therapy in treating a serious illness, it may be appropriate to ask the doctor to have a blood level obtained since blood levels are the most accurate assessment of how CoQ10 is being absorbed and delivered to tissues and organs. When CoQ10 is delivered in sufficient dosage, it will support the tissues in need.
*******Safety********
Consult your doctor before trying CoQ10, especially if you have heart disease, kidney failure, or cancer.
Side effects of CoQ10 may include diarrhea and rash.
CoQ10 is used in combination with standard treatment, not to replace it.
CoQ10 may lower blood sugar levels, so people with diabetes should not use CoQ10 unless under a doctor's supervision.
The safety of Co q10 in pregnant or nursing women or children has not been established.
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